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		</div><p>Assisted reproduction is an “evolutionary experiment” that could prove as big a health disaster as junk food, a scientist has warned.</p>
<p>Dr Pascal Gagneux, an evolutionary biologist from the University of California at San Diego in the US, believes the technology may be storing up serious trouble for ageing populations of IVF children.</p>
<p>Of the estimated five million IVF offspring alive today, the oldest of them, British “test tube baby” Louise Brown, is only 39.</p>
<p>Dr Gagneux fears that unintended and unwanted consequences of IVF, that cannot be detected now, may emerge towards the end of life.</p>
<p>And he points out that scientists have already uncovered ominous signs.</p>
<p>IVF mice that are allowed to age become ill – females develop a pre-diabetic condition called metabolic syndrome, while male animals suffer hormonal problems.</p>
<p>More worrying was one study which involved taking 100 IVF and naturally conceived children aged as young as six 3,500 metres up a Swiss mountain, where low oxygen levels mimic effects of ageing.</p>
<p>Heart and artery malfunction was reported “very convincingly” in the assisted reproduction children, including those with brothers and sisters who were conceived naturally, said Dr Gagneux.</p>
<p>Speaking at the American Association for the Advancement of Science (AAAS) annual meeting in Washington DC, he said: “I’m an evolutionary biologist and interested in human origins. To me this is the epitome of a species taking its own fate into its own hands.</p>
<p>“We’re engaging in an evolutionary experiment … I would compare it to high fructose corn syrup and fast food in the US. It took 50 years; it was fantastic, you got bigger and healthier, and now the US are the first generation that are shorter and heavier and die younger. But it took 50 years.</p>
<p>“I think we can’t rule out that it could be shortening life span. It could also be introducing some very interesting costs in terms of metabolic syndrome.”</p>
<p>One of Dr Gagneux’s biggest concerns was the way IVF embryos were bathed in a cocktail of chemicals for up to five days during the phase when genetic “imprinting” is taking place.<br />
This is a process that switches on some genes, and switches off others, and it has effects that can be passed down generations.</p>
<p>“It could also be introducing some very interesting costs if metabolic syndrome would be one of the potential consequences of starting an embryo out in ‘rocket fuel’, some minestrone mixture that lab people have developed,” said Dr Gagneux.</p>
<p>British experts in the field of reproductive medicine strongly disagreed with the views expressed by Dr Gagneux.</p>
<p>Allan Pacey, Professor of Andrology at the University of Sheffield, said: “There is a wealth of epidemiological evidence to suggest that the babies born through IVF technologies are on the whole as healthy as their naturally conceived counterparts.</p>
<p>“Where some differences have been observed, these are largely explained by genetic defects in the sperm of the father rather than the fact that fertilisation and embryo development occurred outside of the body.</p>
<p>“I don’t share the concerns raised by Dr Gagneux. If we were always led by the precautionary principle, medicine would never make any advances.”</p>
<p>Dr Geoffrey Trew, a gynaecologist from Imperial College London, said: “He’s pulling together several hypothetical ideas that don’t bear extrapolation to what he’s saying – and unnecessarily worrying the millions of parents of children born through IVF. Not good, nor responsible, science.”</p>
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Anything is a health disaster to match junk food.