Scientists identify six different ‘types’ of Covid-19

&Tab;&Tab;<div class&equals;"wpcnt">&NewLine;&Tab;&Tab;&Tab;<div class&equals;"wpa">&NewLine;&Tab;&Tab;&Tab;&Tab;<span class&equals;"wpa-about">Advertisements<&sol;span>&NewLine;&Tab;&Tab;&Tab;&Tab;<div class&equals;"u top&lowbar;amp">&NewLine;&Tab;&Tab;&Tab;&Tab;&Tab;&Tab;&Tab;<amp-ad width&equals;"300" height&equals;"265"&NewLine;&Tab;&Tab; type&equals;"pubmine"&NewLine;&Tab;&Tab; data-siteid&equals;"111265417"&NewLine;&Tab;&Tab; data-section&equals;"2">&NewLine;&Tab;&Tab;<&sol;amp-ad>&NewLine;&Tab;&Tab;&Tab;&Tab;<&sol;div>&NewLine;&Tab;&Tab;&Tab;<&sol;div>&NewLine;&Tab;&Tab;<&sol;div><p>Scientists say they have identified six different &OpenCurlyDoubleQuote;types” of Covid-19&comma; each based on a &OpenCurlyDoubleQuote;particular cluster of symptoms”&period;<br &sol;>&NewLine;Their findings are based on data gathered from King’s College London’s COVID Symptom Study app&period;<&sol;p>&NewLine;<p>The researchers used the data to develop a model to predict which patients are most likely to require hospitalisation and breathing support&comma; based on their earliest symptoms&period; The team said these findings could have &OpenCurlyDoubleQuote;important implications for care and monitoring of people who are most vulnerable to severe Covid-19”&comma; ahead of a second wave of coronavirus infections&period;<&sol;p>&NewLine;<p>According to the researchers&comma; most people who require breathing support come to hospital around 13 days after their first symptoms&comma; so knowing those who are at higher risk of severe infection&comma; as early as day five&comma; could help save lives&period;<&sol;p>&NewLine;<p>Study author Dr Claire Steves&comma; from King’s College London&comma; added&colon;<&sol;p>&NewLine;<p>&OpenCurlyDoubleQuote;If you can predict who these people are at day five&comma; you have time to give them support and early interventions such as monitoring blood oxygen and sugar levels&comma; and ensuring they are properly hydrated – simple care that could be given at home&comma; preventing hospitalisations and saving lives&period;”<&sol;p>&NewLine;<p>Continuous cough&comma; fever and loss of smell are recognised as the three main symptoms of the disease caused by the Sars-Cov-2 virus&period;<&sol;p>&NewLine;<blockquote><p>If you can predict who these people are at day five&comma; you have time to give them support and early interventions such as monitoring blood oxygen and sugar levels&comma; and ensuring they are properly hydrated<&sol;p><&sol;blockquote>&NewLine;<p>But the scientists said data from their app showed a wide range of symptoms associated with Covid-19 such as headaches&comma; muscle pains&comma; fatigue&comma; diarrhoea&comma; confusion&comma; loss of appetite and shortness of breath&period;<&sol;p>&NewLine;<p>The team used machine learning&comma; a type of artificial intelligence&comma; to see whether particular symptoms tend to appear together and whether that had an effect on the progression of the disease&period;<&sol;p>&NewLine;<p>Analysis was made based on the data gathered from around 1&comma;600 users in the UK and US&comma; between March and April&comma; who had a confirmed Covid-19 diagnosis&period; The results showed six specific clusters of symptoms&comma; which according to the researchers&comma; represented six distinct types of Covid-19&period;<&sol;p>&NewLine;<p>These clusters include&colon;<&sol;p>&NewLine;<p>– Flu-like with no fever&colon; Headache&comma; loss of smell&comma; muscle pains&comma; cough&comma; sore throat&comma; chest pain&comma; no fever<&sol;p>&NewLine;<p>– Flu-like with fever&colon; Headache&comma; loss of smell&comma; cough&comma; sore throat&comma; hoarseness&comma; fever&comma; loss of appetite<&sol;p>&NewLine;<p>– Gastrointestinal&colon; Headache&comma; loss of smell&comma; loss of appetite&comma; diarrhoea&comma; sore throat&comma; chest pain&comma; no cough<br &sol;>&NewLine;– Severe level 1&comma; fatigue&colon; Headache&comma; loss of smell&comma; cough&comma; fever&comma; hoarseness&comma; chest pain&comma; fatigue<br &sol;>&NewLine;– Severe level 2&comma; confusion&colon; Headache&comma; loss of smell&comma; loss of appetite&comma; cough&comma; fever&comma; hoarseness&comma; sore throat&comma; chest pain&comma; fatigue&comma; confusion&comma; muscle pain<&sol;p>&NewLine;<p>– Severe level 3&comma; abdominal and respiratory&colon; Headache&comma; loss of smell&comma; loss of appetite&comma; cough&comma; fever&comma; hoarseness&comma; sore throat&comma; chest pain&comma; fatigue&comma; confusion&comma; muscle pain&comma; shortness of breath&comma; diarrhoea&comma; abdominal pain&period;<&sol;p>&NewLine;<p>The researchers said they recently identified skin rash as another key symptom of Covid-19 but it was not recognised as a symptom during the time when the data was gathered for their analysis – so it is currently unknown how skin rashes map on to these six clusters&period;<&sol;p>&NewLine;<blockquote><p>Being able to gather big datasets through the app and apply machine learning to them is having a profound impact on our understanding of the extent and impact of Covid-19&comma; and human health more widely<&sol;p><&sol;blockquote>&NewLine;<p>The researchers said they tested their machine learning technology on another dataset&comma; which included 1&comma;000 users in the UK&comma; US and Sweden&comma; who had logged their symptoms during May&comma; and found similar results&period; The team also found that those who belonged to severe level 1&comma; 2 and 3 cluster types were more likely to be older and frailer&comma; be overweight&comma; and have underlying conditions such as diabetes or lung disease&period;<&sol;p>&NewLine;<p>The researchers then developed a model to predict which cluster a patient falls into&comma; and their risk of requiring hospitalisation and breathing support&comma; based purely on age&comma; sex&comma; BMI and pre-existing conditions alone&period; They believe prediction tools like these could provide an early warning sign as to who is most likely to need more intensive care&comma; based on their early symptoms&period;<&sol;p>&NewLine;<p>Sebastien Ourselin&comma; professor of healthcare engineering at King’s College London and senior author on the study&comma; said&colon;<&sol;p>&NewLine;<p>&OpenCurlyDoubleQuote;Being able to gather big datasets through the app and apply machine learning to them is having a profound impact on our understanding of the extent and impact of Covid-19&comma; and human health more widely&period;”<&sol;p>&NewLine;<p>The study is published in a pre-print server called medRxiv&comma; and is yet to be peer reviewed&period;<&sol;p>&NewLine;&Tab;&Tab;&Tab;<div style&equals;"padding-bottom&colon;15px&semi;" class&equals;"wordads-tag" data-slot-type&equals;"belowpost">&NewLine;&Tab;&Tab;&Tab;&Tab;<div id&equals;"atatags-dynamic-belowpost-68ed82e295ef8">&NewLine;&Tab;&Tab;&Tab;&Tab;&Tab;<script type&equals;"text&sol;javascript">&NewLine;&Tab;&Tab;&Tab;&Tab;&Tab;&Tab;window&period;getAdSnippetCallback &equals; function &lpar;&rpar; &lbrace;&NewLine;&Tab;&Tab;&Tab;&Tab;&Tab;&Tab;&Tab;if &lpar; false &equals;&equals;&equals; &lpar; window&period;isWatlV1 &quest;&quest; false &rpar; &rpar; &lbrace;&NewLine;&Tab;&Tab;&Tab;&Tab;&Tab;&Tab;&Tab;&Tab;&sol;&sol; Use Aditude scripts&period;&NewLine;&Tab;&Tab;&Tab;&Tab;&Tab;&Tab;&Tab;&Tab;window&period;tudeMappings &equals; window&period;tudeMappings &vert;&vert; &lbrack;&rsqb;&semi;&NewLine;&Tab;&Tab;&Tab;&Tab;&Tab;&Tab;&Tab;&Tab;window&period;tudeMappings&period;push&lpar; 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