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		</div><p>An effective HIV vaccine may be a short step away now scientists have overcome a major stumbling block hindering its development. The big hurdle has been the inability to generate immune cells that stay in circulation long enough to stop the Aids virus spreading.</p>
<p>International researchers believe they have solved the problem by &#8220;unblocking&#8221; a process linked to an HIV protein that was halting the production of antibody-generating &#8220;B-cells&#8221; from the immune system.<br />
Lead scientist Professor Jonathan Heeney, from Cambridge University, said: &#8220;For a vaccine to work, its effects need to be long lasting.</p>
<p>&#8220;It isn&#8217;t practical to require people to come back every six to 12 months to be vaccinated. We wanted to develop a vaccine to overcome this block and generate these long-lived antibody producing cells. We have now found a way to do this.</p>
<p>&#8220;What we have found is a way to greatly improve B-cell responses to an HIV vaccine. We hope our discovery will unlock the paralysis in the field of HIV vaccine research and enable us to move forward.&#8221; The researchers compared their achievement, reported in the Journal of Virology, to &#8220;preventing a key getting stuck in a lock&#8221;.</p>
<p>In laboratory experiments the new approach produced desired immune system responses that lasted more than a year. In future it should be possible to produce vaccines that stimulate long-lasting B-cell responses against HIV, the scientists believe.</p>
<p>Prof Heeney added: &#8220;B-cells need time to make highly effective neutralising antibodies, but in previous studies B-cell responses were so short lived they disappeared before they had the time to make all the changes necessary to create the &#8216;silver bullets&#8217; to stop HIV.</p>
<p>&#8220;We hope our discovery will unlock the paralysis in the field of HIV vaccine research and enable us to move forward.&#8221;</p>
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