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		</div><p>Serena Williams will start her bid for a seventh US Open singles crown against familiar foe Maria Sharapova.</p>
<p>Williams’ match-up with Sharapova is the pick of the women’s first-round draw.</p>
<p>Sharapova upset Williams to win the Wimbledon title in 2004, a result which prevented the American from claiming a third consecutive title at SW19.</p>
<blockquote class="twitter-tweet" data-width="550" data-dnt="true">
<p lang="en" dir="ltr">One for the ages&#8230;ð¤¯ð²</p>
<p>Serena Williams will face Maria Sharapova in R1 for their first ever meeting in Flushing Meadows!<a href="https://twitter.com/hashtag/USOpen?src=hash&;ref_src=twsrc%5Etfw">#USOpen</a> <a href="https://t.co/T4kSoUdniZ">pic.twitter.com/T4kSoUdniZ</a></p>
<p>&mdash; US Open Tennis (@usopen) <a href="https://twitter.com/usopen/status/1164571994865766401?ref_src=twsrc%5Etfw">August 22, 2019</a></p></blockquote>
<p><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></p>
<p>But 23-times Grand Slam singles champion Williams holds a convincing 19-2 lead in their head-to-head battles, with the 2012 Olympics, 2013 French Open and 2015 Australian Open among her final victories over the Russian.</p>
<p>Number one seed Naomi Osaka starts the defence of her title against Russia’s Anna Blinkova.</p>
<p>Wimbledon sensation Cori Gauff has a fascinating first-round tie with Anastasia Potapova.</p>
<p>The 15-year-old Gauff reached the fourth round at SW19 and received a wild card to play at Flushing Meadows.</p>
<p>Russian Potapova is a former junior number one, as well as the 2016 Wimbledon girls’ singles champion.</p>
<blockquote class="twitter-tweet" data-width="550" data-dnt="true">
<p lang="en" dir="ltr">The defending champion draws Carballes Baena in R1&#8230;</p>
<p>Projected QF: (5) Medvedev<a href="https://twitter.com/hashtag/USOpen?src=hash&;ref_src=twsrc%5Etfw">#USOpen</a> | <a href="https://twitter.com/DjokerNole?ref_src=twsrc%5Etfw">@DjokerNole</a> <a href="https://t.co/HyboakYllY">pic.twitter.com/HyboakYllY</a></p>
<p>&mdash; US Open Tennis (@usopen) <a href="https://twitter.com/usopen/status/1164577383611031552?ref_src=twsrc%5Etfw">August 22, 2019</a></p></blockquote>
<p><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></p>
<p>Three-time champion Novak Djokovic, the number one seed, begins the defence of his title against Spain’s Roberto Carballes Baena.</p>
<p>Djokovic is in the same half of the draw as five-time champion Roger Federer, who will play a qualifier in the first round, and is projected to meet the dangerous Russian Daniil Medvedev in the quarter-final.</p>
<p>Second seed Rafael Nadal has a tricky opening against John Millman, the Australian who beat Federer in four sets at the US Open 12 months ago.</p>
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