Smith, Coldplay and The Who will be flying the Union Jack at the iHeartRadio music festival in Las Vegas.
Disclosure – who have collaborated with Sam on the new track Omen – and Duran Duran are also confirmed to take to the stage.
Kanye West, Janet Jackson, Lil Wayne and the Weeknd will also perform during the two-day event in Las Vegas in September.
Other performers include David Guetta, Kenny Chesney, Fall Out Boy, Prince Royce, Diplo, the Killers, Jason Derulo and Blake Shelton.
Ryan Seacrest will host the festival, which is now in its fifth year.
The iHeartRadio music festival, which will live stream on Yahoo! and iHeartMedia’s radio stations, will take place at the MGM Grand Garden Arena from September 18 and 19.
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