Joe Biden and Kamala Harris have accused Donald Trump of rooting for violence amid unrest in Wisconsin and attacked him for a lack of leadership on the coronavirus pandemic.
Their comments came hours before Mr Trump’s planned address on the final night of the Republican National Convention.
“He views this as a political benefit,” Democratic presidential nominee Mr Biden said on MSNBC about protests in Wisconsin after police shot a black man earlier this week.
“He’s rooting for more violence, not less. And it’s clear about that.”
Ms Harris, the vice presidential nominee, said Mr Trump has showed “a reckless disregard for the well-being of the American people” in failing to contain the coronavirus.
It was her first major Trump-focused speech since she joined the Democratic ticket.
The two had been largely silent during the first three days of the Republican convention, during which Republicans have tried to link them to protesters, warning a Biden presidency would make America less safe and erroneously saying he wants to defund the police.
Meanwhile, the police shooting of Jacob Blake in Kenosha, Wisconsin, has once again sparked protests against racial injustice and police brutality.
Days later, a 17-year-old white gunman was arrested in connection with the fatal shooting of two protesters in clashes between vigilante militias and demonstrators.
White House adviser Kellyanne Conway suggested on Fox & Friends that the Wisconsin unrest could help Mr Trump’s reelection chances.
“The more chaos and anarchy and vandalism and violence reigns,” Ms Conway said, “the better it is for the very clear choice on who’s best on public safety and law and order.”
Mr Biden does not support defunding the police but has advocated for overhauling US police practices after years of high-profile killings of black Americans by officers.
Ms Harris, meanwhile, sponsored a Bill in Congress to ban certain police practices like chokeholds and no-knock warrants and would create a national registry for police misconduct, among other things.
In Washington on Thursday, Ms Harris defended the protesters in remarks sure to give fuel to Mr Trump on the convention’s final night.
“It’s no wonder people are taking to the streets — and I support them,” she said. “Make no mistake: we will not let these vigilantes and extremists derail the path to justice.”
Mr Biden, who has largely limited travel to near his home in Wilmington, Delaware, during the pandemic said he would consider travelling to Kenosha.
“If I were president I’d be going,” Mr Biden said. “But it’s hard to tell now what the circumstance on the ground is.”
Should he make the trip, Mr Biden said, he would attempt to “pull together the black community as well as the white community and sit down and talk about how we get through this”.