Around 100 firefighters were battling a blaze at a five-storey hotel in west London in the early hours of Wednesday.
Up to 160 people were evacuated from the building and there were no injures, according to the London Fire Brigade.
Fifteen fire engines were attending the incident in High Street, Brentford, which started in a bin room adjacent to the Travelodge.
Station commander Nathan Hobson said: “The whole of a single-storey bin room on the ground floor is alight. The fire spread to an adjacent hotel of five floors.”
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He said firefighters were carrying out a “systematic search of the hotel” after 17 calls were placed to 999.
The brigade was called to the fire at 2.52am and has been supported by staff from surrounding fire stations.
The cause of the fire is not yet known.